基于催产素的抗焦虑作用向临床转化的研究进展

Progress based on the clinical translation of the anxiolytic effects of oxytocin

焦虑障碍的病因及发病机制未明,治疗方面的进展有限,疾病的治愈率低而复发率高。近年来,催产素因其抗焦虑作用引起了人们的关注,尤其在动物实验中得到了验证,但相关的人类研究仍较少。因此,本文对近年来有关催产素与焦虑的研究进行综述,以期更深入地理解焦虑的病理机制。焦虑障碍是最常见的精神障碍之一,神经递质的失衡被认为是其发生的原因之一。催产素作为脑内一种常见的神经递质参与了焦虑情绪调节的过程。本文目的是通过总结与催产素相关的基础研究,探索其调节焦虑的可能机制,并结合临床研究结果,为焦虑障碍的诊断和治疗提供新思路。

The etiology and pathogenesis of anxiety disorders were still unknown with limited progress in treatment,and had a low cure rate and a high relapse rate.Oxytocin has attracted attention in recent years due to its anxiolytic effect,especially validated in animal experiments,but there are few studies in humans.Therefore,the purpose of this paper is to illustrate the pathological mechanism of anxiety through review researches on oxytocin and anxiety in recent years.Anxiety disorder is one of the most common mental disorder,and the imbalance of neurotransmitters is one of the pathogenesis.As a common neurotransmitter in the brain,oxytocin participated in the process of anxiety regulation.The purpose of this article is to summarize the research related to oxytocin to explore its possible mechanism of regulating anxiety,and to provide new ideas for diagnosis and treatment of anxiety disorders in combination with the clinical findings.