细胞治疗遗传性大疱性表皮松解症研究进展

Cell therapy for hereditary epidermolysis bullosa

遗传性大疱性表皮松解症(EB)是一种罕见的残毁型、致死型单基因遗传性皮肤病,对社会和家庭造成了沉重负担。细胞疗法因其卓越稳定的临床疗效成为EB治疗中极有前景的一种手段,本文从干细胞和体细胞两方面总结近年来细胞疗法在EB的实验室研究及临床应用方面的进展。

Hereditary epidermolysis bullosa(EB)is a rare mutilating and lethal inherited single-gene skin disease,and places a heavy burden on society and families.Cell therapy has become a very promising method for the treatment of EB due to its excellent and stable clinical efficacy.This review summarizes progress in laboratory research and clinical application of stem cell-and somatic cell-based therapies in EB in recent years.