自身免疫性疱病的表位扩展现象

Epitope spreading in autoimmune bullous diseases

表位扩展常发生在自身免疫性疱病患者中,该类患者由于表位扩展使得更多的抗原表位暴露,引起原疾病加重、转化或并发其他疾病。随着表位扩展的免疫学证据日益增加,越来越多的学者认识到表位扩展在疾病发展的过程中发挥重要作用。本文从不同类型类天疱疮、不同类型天疱疮、天疱疮与类天疱疮、自身免疫性疱病与其他皮肤病的并发或转化四个方面,介绍自身免疫性疱病中的表位扩展现象。

Epitope spreading often occurs in patients with autoimmune bullous diseases(ABDs),resulting in exposure of more antigenic epitopes,aggravation or transformation of pre-existing diseases,or concurrence of other diseases.With the increase in the immunological evidence for epitope spreading,more and more scholars have realized that epitope spreading plays an important role in the development of ABDs.This review introduces the phenomenon of epitope spreading in ABDs from 4 aspects,including the concurrence or transformation between different types of pemphigoid,different types of pemphigus,pemphigus and pemphigoid,as well as between ABDs and other skin diseases.