上海市松江区社区居民血清谷丙转氨酶与2型糖尿病相关性研究

Association between serum alanine transaminase and type 2 diabetes mellitus among community residents in Songjiang District,Shanghai Municipality

目的了解上海市松江区社区居民中血清谷丙转氨酶(ALT)与2型糖尿病(T2DM)的关系,为糖尿病的早期防控提供理论依据。方法对上海市松江区32695名20~74岁常住居民进行问卷调查及体格检查,并检测血清谷丙转氨酶、血糖、血脂等生化指标,分析ALT与T2DM的关系。结果检出T2DM 4883人,患病率为14.94%。多因素logistic回归分析发现,调整年龄、婚姻、文化程度、吸烟、饮酒、血压、超重、中心性肥胖、尿酸、血脂等可能的混杂因素后,ALT异常组患T2DM的风险是正常组的1.917倍(95%CI:1.716~2.143),在男性和女性居民中的风险分别为1.787倍(95%CI:1.521~2.091)和2.047倍(95%CI:1.747~2.400)。结论上海市松江区社区居民ALT异常是T2DM患病危险因素,在糖尿病防控中需关注ALT水平。

Objective To examine the association between serum alanine transaminase(ALT)and type 2 diabetes mellitus(T2DM)among community residents in Songjiang District,Shanghai Municipality;to provide insights into early management of diabetes.Methods Questionnaire survey and physical examinations were performed among 32695 permanent residents at ages of 20 to 74 years in Songjiang District,Shanghai Municipality,and serum ALT,blood glucose and blood lipids were measured.The correlation between serum ALT and T2DM was examined.Results A total of 4883 residents were detected with T2DM,with a prevalence of 14.94%.Multivariate logistic regression analysis showed that the risk of T2DM was 1.917-fold higher among residents with abnormal ALT than those with normal ALT[95%confidential interval(CI):(1.716,2.143)],1.787-fold higher among male residents with abnormal ALT than those with normal ALT[95%CI:(1.521,2.091)],and 2.047-fold higher among female residents with abnormal ALT than those with normal ALT[95%CI:(1.747,2.400)].Conclusion Abnormal ALT is a risk factor for T2DM among community residents in Songjiang District,Shanghai Municipality,and serum ALT requires to be paid more attention to for the management of diabetes.