糖尿病与血管性痴呆发病的关联、病理机制及防治策略研究

Association,pathological mechanisms,prevention and control strategies of diabetes and vascular dementia:a review

血管性痴呆发病率逐年上升,目前缺乏有效治疗方法,因此降低血管性痴呆发病风险至关重要。研究表明糖尿病与血管性痴呆发病存在关联。本文收集1995年1月—2023年4月糖尿病与血管性痴呆相关的研究文献,对糖尿病与血管性痴呆发病的关联、病理机制和防治策略进行综述,发现糖尿病可通过诱导脑血管病、氧化应激和炎症反应加快血管性痴呆的发生发展,使用降糖药物、去除脑血管病诱因、维持血脑屏障稳定和坚持健康生活方式是现阶段血管性痴呆防治的主要措施。今后需进一步探索糖尿病诱发血管性痴呆的机制,寻求经济有效的防治靶点。

The incidence rate of vascular dementia is increasing year by year,and there is still no effective treatment at present,so it is very important to reduce the risk of developing vascular dementia.Research shows that diabetes is associated with vascular dementia.Based on the research literature related to diabetes and vascular dementia from January 1995 to April 2023,This article reviews the relationship between diabetes and vascular dementia,pathological mechanism and prevention and control strategies.It is found that diabetes can promote the occurrence and development of vascular dementia by inducing cerebrovascular disease,oxidative stress and inflammatory reaction,using hypoglycemic drugs,removing the incentives of cerebrovascular disease,maintaining the stability of blood-brain barrier and adhering to a healthy lifestyle are the main measures for the prevention and control of vascular dementia at this stage.Future research needs to further explore the mechanism of vascular dementia induced by diabetes,and seek economic and effective prevention targets.