癃清片及盐酸坦洛新缓释片围术期联合用药对前列腺增生症患者术后排尿功能的影响

Effect of perioperative combined use of Longqing Tablets and Tamsulosin Hydrochloride Sustained-Release Tablets on postoperative urination function of patients with prostatic hyperplasia

目的观察围术期予以癃清片联合盐酸坦洛新缓释片治疗对前列腺增生症患者术后排尿功能的影响。方法将2020年4月至2021年10月该院泌尿外科收治的120例前列腺增生症患者分为手术组、坦洛新组、癃清片组和联合用药组,每组30例。4组患者均行经尿道等离子电切(TPKRP)术。手术组单纯行TPKRP术,坦洛新组围术期口服盐酸坦洛新缓释片治疗,癃清片组围术期口服癃清片治疗,联合用药组围术期口服癃清片联合盐酸坦洛新缓释片治疗。对比4组患者治疗前后生活质量评分(QOL)、国际前列腺症状评分(IPSS)、中医症状评分、最大尿流率、膀胱最大容量、残余尿量、最大逼尿肌压等。结果与癃清片组、坦洛新组、手术组比较,联合用药组患者QOL、IPSS降低更明显,最大尿流率提高更明显,术后膀胱残余尿量、最大逼尿肌压力下降更明显,差异均有统计学意义(P<0.05);联合用药组患者中医症状评分明显低于癃清片组,差异有统计学意义(P<0.05)。4组患者治疗前后膀胱最大容量比较,差异均无统计学意义(P>0.05)。结论围术期给予癃清片联合盐酸坦洛新缓释片治疗可促进患者术后排尿功能恢复,改善患者生活质量。

Objective To observe the effect of perioperative combined use of Longqing Tablets combined with Tamsulosin Hydrochloride Sustained-Release Tablets on postoperative urinary function in the patients with prostatic hyperplasia.Methods A total of 120 patients with prostatic hyperplasia treated in the urologic surgery department of this hospital from April 2020 to October 2021 were randomly divided into the surgery group,tamsulosin group,Longqing Tablets group and combined medication group,30 cases in each group.The patients in the four groups all underwent the transurethral plasma resection of prostate(TPKRP),the surgery group conducted the simple TPKRP,the Longqing Tablets group orally took Longqing Tablets during the perioperative period and the combine medication group orally took Longqing Tablets combined with Tamsulosin Hydrochloride Sustained-Release Tablets during the perioperative period.The quality of life(QOL)score,International Prostate Symptom Scale(IPSS)score,TCM symptom score,maximum urinary flow rate,maximum bladder capacity,residual urine volume and maximum detrusor pressure before and after treatment were compared among the 4 groups.Results Compared with the Longqing Tablet group,Tamsulosin group and operation group,the decrease of QOL score and IPSS score in the combined drug group were more significant,the increase of postoperative maximum urinary flow rate was more significant,the decrease of postoperative bladder residual urine volume and maximum detrusor pressure was more significant,and the differences were statistically significant(P<0.05).The score of Chinese medicine symptoms in the combined medication group was significantly lower than that in the Longqing Tablets with statistical difference(P<0.05).The maximum bladder capacity before and after treatment had no statistical difference among 4 groups(P>0.05).Conclusion Giving Longqing Tablets combined with Tamsulosin Hydrochloride Sustained-Release Tablets during the perioperative period could promote the postoperative recovery of urinary function in the patients and improve the quality of life of the patients.