肠道菌群代谢物与高血压关系的研究进展

Research progress on relationship between intestinal flora metabolites and hypertension

高血压是危害性较大的慢性心血管疾病,呈发病率逐年攀升与发病患者年轻化趋势,已成为全球性的公共卫生问题。高血压是多种因素协同作用的结果,主要涉及环境因素和遗传因素,但其具体发病机制尚不明确。近年来,大量科学研究表明肠道菌群与高血压之间存在密切联系,特别是肠道菌群代谢物可通过多种途径对血压进行调控,影响高血压进展。该文阐述了肠道菌群主要代谢物参与血压调控的机制,以期为防治高血压提供新的思路和靶点。

Hypertension is a chronic cardiovascular disease with high hazards,its prevalence rate is increasing year by year and the patients are getting younger,which has become a global public health problem.Hypertension is the result of synergistic effects of many factors,mainly involving in the environmental factors and genetic factors,but its specific pathogenesis is still unclear.In recent years,a large number of scientific studies have shown that there is a close relationship between intestinal flora and hypertension,especially the metabolites of intestinal flora can regulate the blood pressure through various channels and affect the progress of hypertension.This paper expounds the mechanism of the main metabolites of intestinal flora participating in the regulation of blood pressure to provide the new ideas and targets for the prevention and treatment of hypertension.