摘要
小气道病变作为慢性阻塞性肺疾病(COPD)的主要病理过程,在COPD的预防、进展及靶向治疗过程中发挥至关重要的作用,因此小气道病变检测是攻克COPD防治的重要一环。目前检测小气道病变的方法有肺量计、脉冲振荡、体积描记法、气体稀释法、部分呼出气一氧化氮、放射影像学等。本文就COPD小气道生理结构、小气道病变的检测方法,着重于每种检测方法当前的研究进展及优缺点作以下综述。
Small airway disease(SAD),as the main pathological process of chronic obstructive pulmonary disease(COPD),plays an important role in the prevention,progress,and targeted therapy of COPD.Therefore,the detection of SAD plays an important part in the prevention and treatment of COPD.At present,detection methods of SAD include spirometer measurement,impulse oscillometry,plethysmography,single or multiple breath washout,partial exhaled nitric oxide,radiography,etc.This review aims to summarize the advantages and disadvantages of different detection methods of SAD based on the structure of small airway.
作者
曾肖幔
张新日
乔可宏
曹大伟
Zeng Xiaoman;Zhang Xinri;Qiao Kehong;Cao Dawei(The First Clinical Medical School of Shanxi Medical University,Taiyuan 030001,China;NHC Key Laboratory of Pneumoconiosis,Shanxi Province Key Laboratory of Respiratory,Department of Pulmonary and Critical Care Medicine,the First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Respiratory and Critical Care Medicine,Taiyuan Hospital,Peking University First Hospital,Taiyuan 030000,China)
出处
《国际呼吸杂志》
2023年第6期719-723,共5页
International Journal of Respiration
基金
中央级公益性科研院所科研业务项目(2020-PT320-005)。
关键词
肺疾病
慢性阻塞性
小气道
小气道病变
Pulmonary disease,chronic obstructive
Small airway
Small airway disease
