血清IL-17A、TGF-β对高级别CIN患者术后复发的预测价值

The predictive value of serum IL-17A and TGF-β for postoperative recurrence in high-grade CIN patients

目的 分析血清白细胞介素(IL)-17A、转化生长因子-β(TGF-β)对高级别宫颈上皮内瘤变(CIN)患者术后复发的预测价值。方法 选取223例行宫颈锥切术的高级别CIN患者,随访1年,根据复发情况分为复发组与未复发组。多因素Logistic回归分析血清IL-17A、TGF-β水平与高级别CIN患者术后复发的关系。ROC曲线分析IL-17A、TGF-β预测高级别CIN患者术后复发的价值。决策曲线分析指标联合的预测价值。结果 复发组血清IL-17A、TGF-β水平高于未复发组(P<0.05);回归分析结果显示,术前血清高水平IL-17A、TGF-β为术后复发的危险因素(P<0.05);ROC曲线显示,术前血清IL-17A、TGF-β预测术后复发风险的AUC均>0.80;决策曲线显示,联合预测优于单独预测。结论 血清IL-17A、TGF-β对高级别CIN患者术后复发具有一定预测价值,联合预测优于单独预测。

Aim To analyze the predictive value of serum interleukin(IL)-17A and transforming growth factor-β(TGF-β)for postoperative recurrence in high-grade cervical intraepithelial neoplasia(CIN)patients.Methods 223 high-grade CIN patients who underwent cervical conization were selected,followed up for 1 year,and divided into recurrent group and non-recurrent group according to the recurrence situation.Multivariate Logistic regression analysis was used to analyze serum IL-17 A,TGF-βlevels and postoperative recurrence in patients with high-grade CIN.ROC curve was analyzed the value of IL-17 A and TGF-βin predicting postoperative recurrence in patients with high-grade CIN.Index joint predictive value was analyzed by decision curve.Results The serum levels of IL-17A and TGF-βin the recurrent group were higher than those in the non-recurrent group(P<0.05).The regression analysis results showed that high levels of IL-17A and TGF-βin preoperative serum was a risk factor for postoperative recurrence(P<0.05).The ROC curve showed that the AUC of preoperative serum IL-17A and TGF-βpredicting postoperative recurrence risk was>0.80.The decision curve showed that joint prediction was superior to individual prediction.Conclusion Serum IL-17A and TGF-βhave certain predictive value for postoperative recurrence in high-grade CIN patients,and combined prediction is better than single prediction.