载脂蛋白E在胆固醇逆向转运中作用的研究进展

The role of apolipoprotein E in reverse cholesterol transport

载脂蛋白E(ApoE)是一种多功能蛋白质,参与血浆脂蛋白的清除、荷脂细胞的胆固醇外流及逆向转运等多种生理过程,降低人体低密度脂蛋白和极低密度脂蛋白的含量,从而降低患动脉粥样硬化(As)等心血管疾病的概率。基于对ApoE结构功能和作用机制的认识,ApoE模拟肽类药物为治疗As等心血管疾病提供新的方向。本文主要对ApoE在细胞胆固醇流出及胆固醇逆向转运等生理过程中的作用机制和ApoE模拟肽类药物研究进展进行综述,以期为As的防治提供新的思路。

Apoprotein E(ApoE),a multifunctional protein,participates in many physiological processes such as plasma lipoprotein clearance,cholesterol efflux and reverse transport of lipoid-bearing cells,which reduces the contents of human low density lipoprotein and very low density lipoprotein,thus reducing the probability of cardiovascular diseases such as atherosclerosis(As).Based on the understanding of the structure,function and mechanism of ApoE,ApoE mimic peptides provides a new direction for the treatment of cardiovascular diseases such as As.In this paper,the mechanism of ApoE in cellular cholesterol efflux and cholesterol reverse transport and the research progress of ApoE mimic peptides is mainly reviewed,with a view to providing new ideas for the prevention and treatment of As in the future.