72组婴幼儿血管瘤双胞胎患儿临床特点分析

Analysis of clinical characteristics of 72 groups of twins with infantile hemangioma

目的分析婴幼儿血管瘤(infantile hemangioma,IH)在双胞胎患儿中的临床特点并探讨其发病机制。方法回顾性分析2016年5月至2021年6月就诊于广东省妇幼保健院及河南省人民医院的72组IH双胞胎患儿,其中双胞胎共同患病25组,仅一方患病47组,采用χ^(2)检验统计分析性别、双胞胎卵型、辅助生殖等因素与双胞胎患病情况的相关性。结果双方均患IH的25组双胞胎中女双胞胎为22组,男双胞胎2组,龙凤胎1组;同卵双胞胎24组,异卵双胞胎1组;人工受孕双胞胎16组,自然受孕双胞胎9组;早产双胞胎20组,非早产双胞胎5组。仅一方患IH的47组双胞胎中女双胞胎为17组,男双胞胎25组,龙凤胎5组;同卵双胞胎37组,异卵双胞胎10组;人工受孕双胞胎8组,自然受孕双胞胎39组;早产双胞胎21组,非早产双胞胎26组。且一方患IH的47组双胞胎中,89.4%(42/47)的患儿为体重减低的一方。经统计学分析,双胞胎是否共同患病与性别具有相关性(χ^(2)=17.84,P<0.05),与双胞胎卵型不具有相关性(χ^(2)=3.76,P>0.05),与辅助生殖具有相关性(χ^(2)=16.21,P<0.05),与早产具有相关性(χ^(2)=8.303,P<0.05),且双胞胎中出生体重较低的一方更易患病。结论双胞胎中IH的临床特点与其总体流行病学特征基本一致,女性、早产、低体重、辅助生殖等均会提高双胎共同患病的概率。

Objective To explore the clinical characteristics of infantile hemangioma(IH)in twin children and to elucidate its pathogenic mechanism.Methods Retrospective review was performed for clinical data of 72 pairs of IH twins admitted into Guangdong Women&Children's Hospital and Henan Provincial People's Hospital from May 2016 to June 2021.Twenty-five pairs of twins had identical diseases while 47 pairs of twins were affected only unilaterally.χ^(2) correlation analysis was performed for examining the influence of such factors as gender,twin zygosity,preterm birth,birth weight and assisted reproduction on clinical characteristics of twins.Results Among 25 pairs of twins with identical diseases,there were 22 pairs of female twins,2 pairs of male twins and 1 pair of pigeon twins;24 pairs of monozygotic twins and 1 pair of dizygotic twins;16 pairs of natural conception and 9 pairs of assisted reproductive twins;20 pairs of preterm born twins and 5 pairs of twins born at term.And among 47 pairs of unilaterally affected twins,there were 17 pairs of female twins,25 pairs of male twins and 5 pairs of pigeon twins;37 pairs of monozygotic twins and 10 pairs of dizygotic twins;8 pairs of natural conception and 39 pairs of assisted reproductive twins;21 pairs of preterm born twins and 26 pairs of twins born at term.Futhermore,for 47 pairs of unilaterally affected twins,89.4%(42/47)of affected twin had a lesser birth weight than the other one.And whether or not twins both have identical diseases was correlated with gender(χ^(2)=17.84,P<0.05)and yet not with twin zygosity(χ^(2)=3.76,P>0.05).It was correlated with assisted reproduction(χ^(2)=16.21,P<0.05)and preterm birth(χ^(2)=8.303,P<0.05).However,individual with lower birth weight in twins was more susceptible.Conclusions Clinical characteristics of IH twins are basically consistent with their epidemiological characteristics.Female,preterm birth,low birth weight and assisted reproduction may elevate the probability of co-morbidity in twins.