肌梭中机械力离子通道及其信号传递机制研究进展

Advances in mechanosensitive ion channels and possible mechanisms of mechanical signal transmission

本体感受器是分布于骨骼肌和关节中感知躯体运动速度、速率变化及姿势维持等本体感觉信号的一类感受器,可将机械力信号转变为电信号并通过传入神经将信息传递至中枢神经系统。该文以脊椎动物最重要的本体感受器——肌梭为例,分析本体感受器中可能存在的离子通道,进一步探讨肌梭将机械力信号转变为电信号的分子机制,为本体感觉的电生理研究、相关药物研发及临床治疗提供一定的分子生物学基础。

Proprioceptors are distributed in skeletal muscles and joints to sense the body’s speed of motion,rate change,posture maintenance and other proprioceptive signals,which can transform mechanical force signals into electrical ones and transmit information to central nerves via afferent nerves.This paper takes proprioception-muscle spindles as an example to analyze the possible ion channels in proprioception-muscle spindles and the molecular mechanism by which muscle spindles transform mechanical force signals into electrical signals,providing molecular biological data for electrophysiological research on proprioception,development of related drugs and clinical treatment.