心房分流器治疗心力衰竭机制及研究进展

Mechanism of atrial shunt device for the treatment of heart failure and its research progress

心力衰竭(简称心衰)是各种心血管疾病终末期表现。心衰恶化是患者反复住院的主要原因。研究证实心衰恶化与死亡率间存在显著相关性。目前单纯药物治疗往往不足以改善心衰患者临床症状和体征,越来越多临床试验研究证实器械治疗可改善患者症状及预后。近年来国内外研究开发的具有独特机制的心房分流器主要有IASD、V-Wave、AFR及D-Shant等,临床应用研究证明,可通过直接降低左心房压力改善心衰患者呼吸困难症状,降低再住院率和病死率,未来可能成为治疗心衰新方法。本文就心房分流器治疗心衰机制及研究进展作一综述。

Heart failure is an end-stage manifestation of various cardiovascular diseases.Deterioration of heart failure is the main cause of repeated hospitalization.Several studies have demonstrated that a significant correlation exists between the worsening of heart failure and the mortality.At present,pharmacotherapy alone is often insufficient to improve the clinical symptoms and signs of patients with heart failure,and more and more clinical trial studies have confirmed that the treatment with an atrial shunt device may improve the patient's symptoms and prognosis.In recent years,a lot of atrial shunt devices carrying unique mechanism have been developed at home and abroad,which mainly include IASD,V-Wave,AFR,D-Shant,etc.Studies of their clinical application have proved that these atrial shunt devices can improve dyspnea symptoms in patients with heart failure through directly reducing the left atrial pressure,which can reduce the re-hospitalization rate and mortality of patients with heart failure,and the use of the atrial shunt device may become a new therapeutic option for heart failure in the future.This paper reviews the mechanism of atrial shunt device in treating heart failure and its recent progress.