细胞因子与自身免疫性甲状腺疾病的相关性研究进展

Research progrress ytokines and autoimmune thyroid disease

自身免疫性甲状腺疾病(autoimmune thyroid disease,AITD)是内分泌系统的一种常见疾病,其具体发病机制尚不明确。AITD是遗传、免疫等因素综合作用的结果。细胞因子是一类具有调节免疫反应能力的小分子蛋白质。本文主要介绍了白细胞介素、干扰素、肿瘤坏死因子与AITD发生发展的关系,综述了其参与AITD的发病机制及作为AITD预测因子的可能性,为细胞因子作为AITD的诊断途径及治疗靶点提供新思路。

Autoimmune thyroid disease(AITD)is a common disease of the endocrine system,and its specific pathogenesis is not clear.AITD is the result of a combination of genetic,immune,and other factors,and cytokines are a kind of small molecular protein with the ability to regulate immune response.This paper mainly introduces the relationship between interleukin,interferon,tumor necrosis factor and the occurrence and development of AITD,and reviews their involvement in the pathogenesis of AITD and their potential as predictive factors for AITD,providing a new idea for using cytokines as the diagnosis pathway and treatment target of AITD.