动物细胞培养基质片状载体的研究及应用进展

Advances in research and application of animal cell culture matrix fibracel carriers

以聚酯纤维为基质的片状载体具有良好的耐酸碱性、耐热性、生物相容性以及不可生物降解、促进细胞黏附和生长等优点。片状载体无动物源性成分,生物安全性高,是细胞培养基质的首选载体之一。近年来,随着生物技术的发展,广泛应用于细胞基质生物制品等研发及生产中。本文对片状载体的结构和细胞培养特点以及在疫苗生产、细胞治疗和组织工程等中的应用作一综述,为片状载体技术后续的进一步研发和应用提供理论依据。

Fibracel carriers based on polyester fiber have the advantages of good acid and alkali resistance,heat resistance,good biocompatibility,non-biodegradation,and can promote cell adhesion and growth.With no animal-derived ingredients and high biological safety,it is one of the preferred carriers for cell culture matrixes,which has been widely used in the development and production of cell matrix biological products with the development of biotechnology in recent years.This paper reviewed the structure and cell culture characteristics of fibracel carriers as well as the applications in vaccine production,cell therapy and tissue engineering,so as to provide a theoretical basis for the further development and application of fibracel carrier technology.