探索终止惊厥性癫痫持续状态的百年老药苯巴比妥

Exploring phenobarbital,a centennial drug,for termination of convulsive status epilepticus

苯巴比妥是治疗癫痫持续状态的百年老药,具有癫痫发作终止率高和复发率低的治疗优势,但也存在呼吸抑制和血压下降等不良反应。中国2016年和2021年2项临床随机对照研究结果提示,对苯巴比妥用药方案进行科学、合理的改进,可在提高安全性的基础上,充分发挥药物的有效性。这些最新研究结果,不仅为专家共识和指南的制订提供了循证依据,更让不能上市新型抗癫痫药的国家或地区,以及不能接受新型抗癫痫药价格的家庭和个人最大程度获益。

Phenobarbital is a centennial drug for the treatment of status epilepticus.It has the advantages of high termination rate and low recurrence rate of seizure,but it also has adverse reactions such as respiratory depression and blood pressure decline.The results of 2 RCT in China in 2016 and 2021 suggest that scientific and reasonable improvement of phenobarbital medication scheme can give full play to drug effectiveness on the basis of improving safety.The latest research results of this old drug not only provide evidence⁃based basis for the development of expert consensus and guidelines,but also maximize the benefits for countries or regions that cannot market new antiepileptic drugs,as well as families and individuals who cannot bear the cost of new antiepileptic drugs.