放射免疫治疗在肿瘤诊疗中的最新研究进展

Recent Advances of Radioimmunotherapy in Tumor Diagnosis and Treatment

放射免疫治疗联合了放射性核素的物理杀伤作用及抗体的靶向特异性,能够有效杀伤肿瘤细胞并减少对健康组织的损害,日益成为肿瘤精准医疗中不可或缺的手段和工具。随着核素制备技术的成熟和抗体药物的广泛临床应用,放射免疫治疗抗体在肿瘤诊疗中也取得了较大进展。结合近年来核素标记抗体药物的临床前研究和临床试验,通过对单克隆抗体、单域抗体及预靶向策略在放射免疫治疗领域的研究进展以及应用价值进行详细介绍,进一步为靶点特异性肿瘤诊疗一体化提供新的思路与方向。

Radioimmunotherapy combines the physical killing effect of radionuclides and the targeting specificity of antibodies,which can effectively kill tumor cells and reduce damage to healthy tissues,and has become an increasingly indispensable means and tool in precision treatment of tumor.With the maturity of nuclide preparation technology and the extensive clinical application of antibody drugs,great progress of radioimmunotherapy antibody has been made in tumor diagnosis and treatment.Based on the preclinical research and clinical trials of radiolabeled antibody drugs in recent years,this article introduces in detail the research progress and application values of monoclonal antibodies,single domain antibodies and pre-targeting strategies in the field of radioimmunotherapy,aiming to provide new ideas and directions for the target-specific paired diagnosis and treatment in tumor.