抗结核固定剂量复合制剂导致急性肾功能损伤1例报道

A case report of acute kidney injury caused by antituberculosis fixed-dose combination formulations

中年男性患者,因咳嗽、双下肢水肿伴少尿入院。患者既往有肺结核、糖尿病史。本次起病诊断肺结核复治,给予口服固定剂量复合制剂抗结核治疗后,出现尿素、肌酐增高。临床诊断为利福平导致的急性肾功能损伤。经过停药、血液透析等治疗后,患者康复出院。通过此病例探讨使用抗结核固定剂量复合制剂导致急性肾功能损伤的可能药物、发生机制,结合分析相关文献,为临床合理用药提供参考。

A middle-aged male patient was admitted to hospital with cough,edema of both lower extremities and oliguria.The patient had a history of pulmonary tuberculosis and diabetes.The onset was diagnosed with pulmonary tuberculosis and re-treatment.After taking oral fixed-dose combination formulations for anti-tuberculosis treatment.Increased urea and creatinine.The clinical diagnosis was Acute kidney injury caused by rifampicin.After drug withdrawal and hemodialysis,the patient recovered and was discharged from the hospital.This case was used to explore the possible drugs and the mechanism of acute kidney injury by the use of antituberculosis fixed-dose combination formulations,and to analyze the relevant literature,so as to provide a reference for clinical rational drug use.