复方苦参注射液联合盐酸羟考酮治疗骨转移癌性疼痛疗效观察

Efficacy observation of compound Kushen injection and oxycodone hydrochloride on bone metastatic carcinoma-caused pain

目的:观察复方苦参注射液联合盐酸羟考酮治疗患者骨转移癌性疼痛疗效。方法:骨转移患者68例分为两组各34例。对照组予三阶梯止痛方案和唑来膦酸治疗,治疗组在对照组基础上用复方苦参注射液治疗,观察两组疼痛缓解率、生活质量评分、镇痛药物每日平均剂量及不良反应发生率。结果:治疗组疼痛缓解总有效率为88.24%,对照组为64.71%,组间差异有统计学意义(P﹤0.05)。两组生活质量均较治疗前明显改善(P﹤0.05),治疗组较对照组改善更显著(P﹤0.05)。治疗组镇痛药物的用量比对照组少,差异有统计学意义(P﹤0.05)。治疗组不良反应发生率为20.58%,对照组为44.12%,组间差异有统计学意义(P﹤0.05)。结论:复方苦参注射液联合盐酸羟考酮治疗骨转移痛更有效,安全性更好。

Objective:To observe the clinical efficacy of compound Kushen injection and oxycodone hydrochloride on bone metastatic carcinoma-caused pain.Methods:68 cases of patients with bone metastatic carcinoma were divided into two groups,34 cases in each group.The control group was treated by three-step analgesic therapy and with zoledronic acid,while the treatment group was treated plus with compound Kushen injection on the basis of control group.The pain relief rate,score of life-quality,average daily dosage of analgesic drugs and incidence rate of adverse reactions were observed in two groups.Results:The total effective rate of pain relief in treatment group was 88.24%,which was higher than 64.71%in control group,and the comparative difference between two groups was statistically significant(P﹤0.05).The quality of life was significantly improved in both groups compared with before treatment(P﹤0.05),and the improvement of treatment group was more significant than that of control group(P﹤0.05).The dosage of analgesic drugs in treatment group was less than that in control group,and the difference was statistically significant(P﹤0.05).The incidence rate of adverse reactions in treatment group was 20.58%,which was lower than 44.12%in control group,and the comparative difference between two groups was statistically significant(P﹤0.05).Conclusion:The clinical efficacy of compound Kushen injection and oxycodone hydrochloride on bone metastatic carcinoma-caused pain is more effective and with better safety.