肠道菌群移植干预自闭症合并胃肠道症状患儿的效果评估

Evaluation of Effect of Intestinal Flora Transplantation Intervention on Children with Autism and Gastrointestinal Symptoms

目的:探究肠道菌群移植干预自闭症合并胃肠道症状患儿的临床效果。方法:招募宜春市人民医院2022年1-7月收治的80例自闭症合并胃肠道症状患儿为对象,根据就诊序号按随机数字表法分为观察组和对照组,每组40例。对照组接受常规康复训练,观察组在此基础上接受肠道菌群移植干预。比较两组患儿的治疗效果、胃肠道症状[胃肠道症状评定量表(gastrointestinal symptom rating scale,GSRS)]、自闭症症状[儿童孤独症评定量表(childhood autism rating scale,CARS)、自闭症行为评定量表(autism behavior checklist,ABC)]、肠道菌群状态(菌群门水平丰度)和不良反应。结果:观察组治疗1、2、3、6个月的有效率均高于对照组,差异均有统计学意义(P<0.05)。治疗1、2、3、6个月,观察组GSRS、CARS、ABC总分均优于对照组,差异均有统计学意义(P<0.05)。治疗1个月,观察组厚壁菌门丰度高于对照组,差异有统计学意义(P<0.05),两组其他菌门丰度比较,差异均无统计学意义(P>0.05)。两组治疗6个月内不良反应发生率比较,差异无统计学意义(P>0.05)。结论:肠道菌群移植干预自闭症合并胃肠道症状患儿效果明显,可通过调节恢复肠道微生物平衡,改善患儿自闭症症状及胃肠道症状。

Objective:To explore the clinical efficacy of intestinal flora transplantation intervention on children with autism complicated with gastrointestinal symptoms.Method:A total of 80 children with autism and gastrointestinal symptoms admitted to Yichun People's Hospital from January 2022 to July 2022 were enrolled as the subjects.According to admission sequence,the children were divided into observation group and control group by the random number table method,with 40 cases in each group.The control group received routine rehabilitation training,and the observation group was given intestinal flora transplantation intervention on this basis.The efficacy,gastrointestinal symptoms[gastrointestinal symptom rating scale(GSRS)],autism symptoms[childhood autism rating scale(CARS),autism behavior checklist(ABC)],intestinal flora status(abundance of flora phylum)and adverse reactions were compared between the two groups.Result:The effective rates at 1 month and 2,3,6 months in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After 1 month and 2,3,6 months of treatment,the total scores of GSRS,CARS and ABC in the observation group were better than those in the control group,the differences were statistically significant(P<0.05).After 1 month of treatment,the richness of firmicutes in the observation group was higher than that in the control group,with statistical significance(P<0.05),while there were no statistical significance in the abundance of other phyla between the two groups(P>0.05).There was no significant difference in the incidence of adverse reactions within 6 months between the two groups(P>0.05).Conclusion:Intestinal flora transplantation intervention has a significant efficacy in the treatment of children with autism and gastrointestinal symptoms.It can improve autism and gastrointestinal symptoms in children by regulating and restoring intestinal microbial balance.