健脾疏肝方联合枸橼酸氯米芬治疗多囊卵巢综合征伴焦虑患者的临床研究

Clinical Study of Jianpi Shugan Formula Combined with Clomifene Citrate in the Treatment of Patients with Polycystic Ovary Syndrome Complicated with Anxiety

目的:探讨健脾疏肝方联合枸橼酸氯米芬治疗多囊卵巢综合征(polycystic ovary syndrome,PCOS)伴焦虑患者的临床效果。方法:选择2019年12月-2020年12月在江西省妇幼保健院中医科门诊就诊的PCOS患者,将其中处于焦虑状态的患者纳入临床研究,共96例。将患者随机分为对照组(n=47)和治疗组(n=49)。在促排卵治疗时,对照组给予枸橼酸氯米芬,研究组在对照组基础上给予健脾疏肝方。比较两组疗效、激素水平、月经周期改善情况及妊娠率。结果:治疗组总有效率为81.63%,高于对照组的53.19%,差异有统计学意义(P<0.05);治疗组抗米勒管激素(anti-Müllerian hormone,AMH)、睾酮(testosterone,T)、黄体生成素(luteinizing hormone,LH)均低于对照组,卵泡激素(follicle-stimulating hormone,FSH)高于对照组,差异均有统计学意义(P<0.05);对照组妊娠率为23.40%,治疗组妊娠率为55.10%,两组比较,差异有统计学意义(P<0.05);两组月经周期改善有效率比较,差异无统计学意义(P>0.05)。结论:健脾疏肝方联合枸橼酸氯米芬较单用枸橼酸氯米芬能更为有效地改善PCOS伴焦虑患者激素水平,提高临床疗效及妊娠率。

Objective:To investigate the clinical effect of Jianpi Shugan Formula combined with Clomifene Citrate in the treatment of patients with polycystic ovary syndrome(PCOS)complicated with anxiety.Method:A total of 96 patients with PCOS complicated with anxiety who were treated in the outpatient Department of Traditional Chinese Medicine of Jiangxi Maternal and Child Health Hospital from December 2019 to December 2020 were included in the clinical study.Patients were randomly divided into control group(n=47)and treatment group(n=49).In ovulation induction treatment,the control group was given Clomifene Citrate,and the treatment group was given Jianpi Shugan Formula on the basis of the control group.The curative effect,hormone level,improvement of menstrual cycle and pregnancy rate were compared between the two groups.Result:The total effective rate in the treatment group was 81.63%,which was higher than 53.19%that in the control group,the difference was statistically significant(P<0.05).The anti-Müllerian hormone(AMH),testosterone(T)and luteinizing hormone(LH)in the treatment group were lower than those in the control group,and the follicle-stimulating hormone(FSH)was higher than that in the control group,the differences were statistically significant(P<0.05).The pregnancy rate in the control group was 23.40%,and that in the treatment group was 55.10%,the difference between the two groups was statistically significant(P<0.05).There was no significant difference in the effective rate of menstrual cycle improvement between the two groups(P>0.05).Conclusion:Jianpi Shugan Formula combined with Clomifene Citrate was more effective than Clomifene Citrate alone in improving the hormone levels,clinical efficacy and pregnancy rate of PCOS patients with anxiety.