区段切除术治疗乳腺癌的作用研究

Effect of Segmental Mastectomy on Breast Cancer

目的:探究区段切除术治疗乳腺癌的作用。方法:本研究以2021年1月-2023年1月宜春新建医院收治的106例乳腺癌患者作为研究对象,按照随机分组原则,分为研究组及对照组,研究组采取区段切除术,对照组采取改良根治术。比较两组围手术期指标、乳腺美学指标、肿瘤标志物、多肽特异性抗原水平及生活质量的差异。结果:研究组术中出血量、手术时间、手术切口长度及住院时间均优于对照组(t=23.362、9.445、6.511、4.001;P=0.000、0.000、0.000、0.000);治疗6周后,研究组乳腺美学指标优良率显著高于对照组(χ^(2)=5.271,P=0.000);两组肿瘤异常蛋白(TAP)、唾液酸(SA)及多肽特异性抗原(TPS)均显著降低,且研究组TAP、SA、TPS均显著低于对照组(t=18.463、59.495、5.744;P=0.000、0.000、0.000);两组生理状况、附加关注程度、情感状况、社会/家庭状况及功能状况显著改善,且研究组生理状况、附加关注程度、情感状况、社会/家庭状况及功能状况评分均显著高于对照组(t=11.428、12.482、13.910、10.656、8.704;P=0.000、0.000、0.000、0.000、0.000)。结论:乳腺癌患者采取区段切除术进行治疗,显著降低肿瘤标志物、多肽特异性抗原水平,显著改善美学指标。

Objective:To explore the effect of segmental mastectomy on breast cancer.Method:In this study,106 patients with breast cancer admitted to Xinjian Hospital,Yichun City from January 2021 to January 2023 were taken as research objects.According to the principle of randomization,the above patients were randomly divided into the study group and the control group.Patients in the study group were treated with segmental mastectomy,while patients in the control group were treated with modified radical mastectomy.Perioperative indexes,breast aesthetic indexes,tumor markers,peptide specific antigen levels and quality of life were compared between the two groups.Result:The intraoperative bleeding volume,operation time,length of surgical incision and hospitalization time of the study group were better than those of the control group(t=23.362,9.445,6.511,4.001;P=0.000,0.000,0.000,0.000).After 6 weeks of treatment,the excellent and good rate of breast aesthetic indexes in the study group was significantly higher than that in the control group(χ^(2)=5.271,P=0.000).After treatment,the levels of tumor abnormal protein(TAP),sialic acid(SA)and polypeptide specific antigen(TPS)in the two groups were significantly decreased,and the levels of TAP,SA and TPS in the study group were significantly lower than those in the control group(t=18.463,59.495,5.744;P=0.000,0.000,0.000).The scores of physiological status,additional attention,emotional status,social/family status and functional status of the two groups were significantly improved,and the scores of physiological status,additional attention,emotional status,social/family status and functional status of the study group were significantly higher than those of the control group(t=11.428,12.482,13.910,10.656,8.704;P=0.000,0.000,0.000,0.000,0.000).Conclusion:Segmental mastectomy of breast cancer can significantly reduce the levels of tumor markers and peptide specific antigen,and significantly improve the aesthetic indicators.