高压氧辅助奥拉西坦治疗急性脑梗死的效果及对内皮细胞功能的影响

Effect of Hyperbarie Oxygen-Assisted Oxiracetam in the Treatment of Acute Cerebral Infarction and the Impact on Endothelial Cell Function

目的探讨高压氧辅助奥拉西坦治疗急性脑梗死(ACI)的效果及对内皮细胞功能的影响。方法选取2021年2月至2023年2月我院收治的76例ACI患者,随机分为观察组与对照组。观察组采用高压氧辅助奥拉西坦治疗,对照组采用奥拉西坦治疗。比较两组的治疗效果、血管内皮细胞功能指标。结果观察组治疗总有效率为97.37%,高于对照组的84.21%(P<0.05)。治疗后,观察组NIHSS评分低于对照组,BI评分高于对照组(P<0.05)。治疗后,两组的ET-1、TXB2水平低于对照组,VEGF水平高于对照组(P<0.05)。结论高压氧联合奥拉西坦治疗ACI的效果较好,可减轻患者的神经功能损伤,改善其日常生活能力及血管内皮功能。

Objective To explore the effect of hyperbaric oxygen-assisted oxacetam in the treatment of acute cerebral infarction(ACI)and the impact on endothelial cell function.Methods 76 ACI patients admitted to our hospital from February 2021 to February 2023 were randomly divided into observation group and control group.The observation group was treated with hyperbaric oxygen-assisted oxacetam,and the control group was treated with oxacetam.The treatment effect and vascular endothelial cell function were compared between the two groups.Results The total effective rate of treament in the observation group was 97.37%,higher than 84.21%in the control group(P<0.05).After treatment,the NIHSS score of observation group was lower than that of the control group,and the BI score was higher than that of the control group(P<0.05).After treatment,the ET-1 and TXB2 levels of the observation group were lower than those of the control group,and the VEGF level was higher than that of the control group(P<0.05).Conclusions Hyperbaric oxygen-assisted oxacetam has better effect in the treatment of ACI,which can reduce the neurological injury and improve the ability of daily living and vascular endothelial function of patients.