血浆FIB、CEA、CA199联合检测对结直肠癌的诊断价值及与TNM分期的关系

Diagnostic Value of Combined Detection of Plasma FIB,CEA and CA199 in Colorectal Cancer and the Correlation with TNM Staging

目的探讨血浆纤维蛋白原(FIB)、癌胚抗原(CEA)、糖类抗原199(CA199)联合检测对结直肠癌的诊断价值及与TNM分期的关系。方法选择2018年10月至2022年10月我院收治的98例结直肠癌患者,比较不同TNM分期结直肠癌患者血浆FIB、CEA、CA199水平,以病理诊断为金标准,分析血浆FIB、CEA、CA199联合检测对结直肠癌的诊断价值。结果随着TNM分期Ⅰ~Ⅳ期增加,结直肠癌患者血浆FIB、CEA、CA199水平逐渐增加(P<0.05)。血浆FIB、CEA、CA199联合检测对结直肠癌诊断的敏感度高于单项检测(P<0.05)。结论血浆FIB、CEA、CA199联合检测对结直肠癌具有较高的诊断价值,三者水平与结直肠癌TNM分期有关,可在一定程度上反映肿瘤进展情况。

Objective To analyze the diagnostic value of combined detection of plasma fibrinogen(FIB),carcinoid antigen(CEA)and carbohydrate antigen 199(CA199)in colorectal cancer and the correlation with TNM staging.Methods 98 patients with colorectal cancer from October 2018 to October 2022 admitted to our hospital were selected,and the plasma FIB,CEA and CA199 levels of colorectal cancer patients with different TNM staging were compared.Taking pathological diagnosis as the gold standard,the diagnostic value of combined detection of plasma FIB,CEA and CA199 of colorectal cancer was analyzed.Results Plasma FIB,CEA and CA199 levels gradually increased in colorectal cancer patients with the escalation of TNM stage Ⅰ~Ⅳ(P<0.05).The sensitivity of combined detection of plasma FIB,CEA and CA199 in the diagnosis of colorectal cancer was higher than that of single detection(P<0.05).Conclusions The combined detection of plasma FIB,CEA and CA199 is of higher value in the diagnosis of colorectal cancer,and the levels of all three are related to the TNM staging of colorectal cancer,which can reflect the tumor progression to a certain extent.