血清鸢尾素、同型半胱氨酸在脑卒中患者中的水平及与血管性认知功能障碍的关系

Serum Irisin and Homocysteine Levels in Patients with Stroke and the Correlation with Vascular Cognitive Impairment

目的探讨血清鸢尾素、同型半胱氨酸(Hcy)在脑卒中患者中的水平及与血管性认知功能障碍(VCI)的关系。方法选取2021年12月至2022年12月我院收治的80例脑卒中患者作为观察组,另选取同期80例健康者为对照组。检测两组血清鸢尾素、Hcy水平,分析其与VCI的关系。结果观察组血清鸢尾素水平低于对照组,Hcy水平高于对照组(P<0.05)。VCI组血清鸢尾素水平低于非VCI组,Hcy水平高于非VCI组(P<0.05)。Logistic回归分析结果显示鸢尾素为VCI的保护因素,Hcy为VCI的危险因素(P<0.05)。联合检测诊断VCI的AUC为0.930,高于鸢尾素、Hcy的0.855、0.848(P<0.05)。结论血清鸢尾素、Hcy与脑卒中后VCI的发生关系密切,早期检测二者水平有助于早期明确VCI的发生情况。

Objective To explore the serum irisin and homocysteine(Hcy)levels in patients with stroke and the correlation with vascular cognitive impairment(VCI).Methods 80 patients with stroke admitted to our hospital from December 2021 to December 2022 were selected as observation group,and 80 healthy people at the same period were selected as control group.The serum irisin and Hcy levels of the two groups were detected,and the correlation with VCI was analyzed.Results The serum irisin level of the observation group was lower than that of the control group,and the Hcy level was higher than that of the control group(P<0.05).The serum irisin level of the VCI group was lower than that of the non-VCI group,and the Hcy level was higher than that of the non-VCI group(P<0.05).Logistic regression analysis showed that irisin was a protective factor for VCI,and Hcy was a risk factor for VCI(P<0.05).The AUC of VCI diagnosed by combined detection was 0.930,higher than 0.855 of irisin and 0.848 of Hcy alone(P<0.05).Conclusions Serum irisin and Hcy are closely related to the occurrence of VCI after stroke.Early detection of irisin and Hcy levels can help identify the VCI early.