玉环市宫颈癌筛查女性HPV感染情况分析

Analysis of HPV infection in women with cervical cancer screening in Yuhuan city

目的分析玉环市宫颈癌筛查女性人乳头瘤病毒(HPV)感染情况,以为玉环市预防和减少宫颈疾病的发生提供参考。方法选取2019年3月至2020年10月于我院进行宫颈癌筛查的10083例女性,均行HPV检测,部分行阴道镜活检、薄层液基细胞学检查。统计HPV检测情况;观察HPV亚型分布,记录单纯感染及多重感染情况;分析HPV亚型与阴道镜活检结果的关系;分析薄层液基细胞学检查结果。结果HPV阴性9031例,HPV阳性1052例,阳性率为10.4%。在1052例HPV阳性患者中,检测到12个高危亚型和1个低危亚型,单纯感染943例(89.6%),多重感染109例(10.4%);多重感染中,双重感染91例(83.5%),三重感染15例(13.8%),四重感染3例(2.8%)。HPV16感染病理结果为阳性者最多,其次为HPV52、18和58。液基细胞学检查结果显示,对照组625例[无上皮内病变或恶性病变(NILM)],占比73.2%;病变组229例[非典型鳞状细胞(ASC)、鳞状上皮内病变、鳞状细胞癌(SCC)],占比26.8%。结论检测HPV亚型在宫颈癌筛查中非常重要,从HPV感染到浸润性宫颈癌需要经历一个漫长的过程。大多数女性HPV感染是暂时的。只有通过早期筛查和早期诊断才能尽快实施有针对性的干预,从而预防和控制疾病的发生、发展。

Objective To analyze the infection of human papillomavirus(HPV)in women with cervical cancer screening in Yuhuan city,so as to provide reference for Yuhuan city to prevent and reduce the occurrence of cervical diseases.Methods A total of 10083 women who underwent cervical cancer screening in our hospital from March 2019 to October 2020 were selected.All of them underwent HPV detection,and some underwent colposcopy biopsy and thin-layer liquid-based cytology.The HPV detection was counted;the distribution of HPV subtypes was observed,and the simple infection and multiple infection were recorded;the relationship between HPV subtypes and colposcopy biopsy results was analyzed;the thin-layer liquid-based cytology results was analyzed.Results There were 9031 cases of HPV-negative and 1052 cases of HPV-positive,and the positive rate was 10.4%.Among the 1052 HPV-positive patients,12 high-risk subtypes and 1 low-risk subtype were detected,including 943 cases of simple infection(89.6%)and 109 cases of multiple infection(10.4%);there were 91 cases(83.5%)of double infection,15 cases(13.8%)of triple infection and 3 cases(2.8%)of quadruple infection in multiple infection.The pathological results of HPV16 infection were the most positive,followed by HPV52,18 and 58.The thin-layer liquid-based cytology results showed that there were 625 cases in the control group[negative for intraepithelial lesion or malignancy(NILM)],accounting for 73.2%;there were 229 cases in the lesion group[atypical squamous cell(ASC),squamous intraepithelial lesion,squamous cell carcinoma(SCC)],accounting for 26.8%.Conclusion The detection of HPV subtypes is very important in cervical cancer screening.From HPV infection to invasive cervical cancer,it takes a long process.Most female HPV infection is temporary.Only through early screening and early diagnosis can targeted interventions be implemented as soon as possible to prevent and control the occurrence and development of the disease.