11058例女性宫颈HR-HPV感染特点分析

Characteristics of cervical HR-HPV infection in 11058 women

目的分析合肥市女性宫颈高危型人乳头瘤病毒(HR-HPV)感染特点及其亚型分布与年龄的关系,为HPV疫苗接种、宫颈癌早期防治提供数据参考。方法选取2021年3月至2023年2月在安徽省第二人民医院就诊并自愿进行高危型HPV(HR-HPV)基因分型检测的11058例女性,受检者被分为5个年龄组(16岁~组、26岁~组、36岁~组、46岁~组、56~88岁组),运用多重荧光PCR技术检测受检者宫颈样本中15种HR-HPV基因亚型的分布情况。结果11058例受检者中HR-HPV阳性者共2321例,HR-HPV感染率为20.99%。不同年龄组中,16岁~组的感染率最高(31.31%,P<0.05)。HR-HPV感染率随感染亚型数目的增加而减少,单一感染率最高,其次为双重感染。16岁~组多重感染率高于其余4组。各年龄组HR-HPV感染的优势亚型是52、53、16和58型,其中52型(5.68%,628/11058)阳性率最高。结论合肥地区女性HR-HPV感染分布存在年龄差异,年轻女性有着最高的感染率和严重的多重感染情况,HR-HPV感染的型别以52、53、16、58型为主。

Objective To analyze the infection status and distribution characteristics between subtypes and age of women in cervical high-risk human papillomavirus(HR-HPV)infection in Hefei,in order to provided the data reference for HPV vaccination and early preven⁃tion and treatment of cervical cancer.Methods From March 2021 to February 2023,a total of 11058 female who voluntarily underwent high-risk HPV(HR-HPV)genotyping test were collected in Anhui No.2 Provincial People’s Hospital.The subjects were divided into five age groups(16~25 years old group,26~35 years old group,36~45 years old group,46~55 years old group,56~88 years old group).Multiplex fluo⁃rescence PCR was used to detect 15 HR-HPV genotypes in cervical samples.Results Among the 11058 tested subjects,2321were positive of HR-HPV.The infection rate of HR-HPV was 20.99%.16~25 years old group had the highest infection rate of HR-HPV among different age groups(31.31%,P<0.05).The infection rate of HR-HPV decreased with the increase of the number of infected subtypes,with the highest single infection rate,followed by double infection.The multiple infection rate of 16~25 years old group was higher than that of the other four groups.The dominant subtypes of HR-HPV infection in each age group were 52,53,16 and 58,with the subtype 52 having the highest positive rate(5.68%,628/11058).Conclusion There is age differences in the distribution of HR-HPV infection among women in Hefei.Young women have the highest infection rate and severe multiple infection.The subtypes of HR-HPV are mainly 52,53,16 and 58.