纤溶酶联合阿司匹林治疗急性脑梗死的效果和安全性

Efficacy and Safety of Plasmin Combined with Aspirin in the Treatment of Acute Cerebral Infarction

目的:探讨纤溶酶联合阿司匹林治疗急性脑梗死的临床治疗效果和安全性。方法:选取2022年1月—2023年1月贵州省安顺市人民医院接受治疗的急性脑梗死患者100例,根据随机数表法分为对照组与观察组,各50例。对照组应用阿司匹林治疗,观察组患者在对照组基础上应用纤溶酶治疗。分析临床治疗效果、血液流变学情况、不良反应情况及神经功能缺损改善情况。结果:观察组临床治疗总有效率高于对照组,差异具有统计学意义(P<0.001)。治疗后,观察组纤维蛋白原水平、血浆黏度、全血高切黏度、全血低切黏度、血细胞比容低于对照组,各项差值高于对照组,差异具有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异具有统计学意义(P=0.012)。治疗后,观察组美国国立卫生研究院卒中量表评分、mRS评分低于对照组,差异具有统计学意义(P<0.001)。结论:在急性脑梗死患者的临床治疗中纤溶酶与阿司匹林联合治疗的疗效可观,可有效改善患者的神经缺损情况与血液流变学情况,不良反应发生率较低,具有较高的临床安全性与有效性。

Objective:To investigate the clinical efficacy and safety of plasmin combined with aspirin in the treatment of acute cerebral infarction.Methods:A total of one hundred patients with acute cerebral infarction who received treatment in Guizhou Anshun People's Hospital from January 2022 to January 2023 were selected and divided into control group and observation group according to random number table method,with fifty patients in each group.The control group was treated with aspirin,and the observation group was treated with plasmin on the basis of control group.The clinical therapeutic effect,hemorheology,adverse reactions and improvement of nerve function defect were analyzed.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.001).After treatment,the fibrinogen level,plasma viscosity,whole blood high tangential viscosity,whole blood low tangential viscosity and hemocytometry volume in observation group were lower than those in control group,and the differences were higher than those in control group,with statistical significance(P<0.05).The total incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P=0.012).After treatment,the National Institutes of Health Stroke Scale score and mRS Score in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.001).Conclusion:In the clinical treatment of patients with acute cerebral infarction,the combined treatment of plasmin and aspirin has a considerable effect,which can effectively improve the nerve defects and hemorheology of patients,and has a low incidence of adverse reactions,and has a high clinical safety and effectiveness.