基于线粒体功能障碍论中药防治特发性肺纤维化的研究进展

Research progress of traditional Chinese medicine in prevention and treatment of idiopathic pulmonary fibrosis based on mitochondrial dysfunction

中医药防治特发性肺纤维化优势显著。线粒体是负责加工、生成人体能量的重要细胞器,线粒体功能障碍引起的代谢障碍、氧化应激损伤、动力学失衡、钙紊乱及线粒体DNA突变与特发性肺纤维化密切相关。基于国内外学者持续关注,维持线粒体功能对治疗特发性肺纤维化至关重要,为中医药干预防治特发性肺纤维化拓展新思路。文章以此新视角作一综述,以期探索改善线粒体功能的中医药靶点,为中药防治特发性肺纤维化提供理论基础。

Traditional Chinese medicine has significant advantages in preventing and treating idiopathic pulmonary fibrosis.Mitochondria is an important organelle responsible for processing and generating human energy.Metabolic disorder,oxidative stress damage,dynamic imbalance,calcium disorder and mitochondrial DNA mutation caused by mitochondrial dysfunction are closely related to idiopathic pulmonary fibrosis.Based on the continuous attention of scholars both domestically and internationally,maintaining mitochondrial function is crucial for the treatment of idiopathic pulmonary fibrosis,expanding new ideas for the prevention and treatment of idiopathic pulmonary fibrosis with traditional Chinese medicine intervention.This article provides a review from this new perspective,with the aim of exploring traditional Chinese medicine targets for improving mitochondrial function,and providing a theoretical basis for the prevention and treatment of idiopathic pulmonary fibrosis with traditional Chinese medicine.