骨肉瘤中医证候要素诊断量表的临床应用

Clinical application of traditional Chinese medicine syndrome element diagnostic scale for osteosarcoma

目的:采用骨肉瘤中医证候要素诊断量表探讨骨肉瘤中医证素分布规律及特征,为中医临床辨证提供参考。方法:采用多中心的调查方法,建立骨肉瘤中医临床调查病例数据库,使用骨肉瘤中医证候要素诊断量表进行中医证素的提取和分析。结果:176例患者中最常见的证素是血瘀证(98例,占55.68%),其次为气虚证(76例,占43.18%)、血虚证(65例,占36.93%),比较少的是气滞证(28例,占15.91%)、痰阻证(26例,占14.77%)。176例骨肉瘤患者中出现了无证型、单证型、双证型组合、三证型组合、四证型组合、五证型组合。其中双证型组合最多,56例,占31.82%;无证型10例,占5.68%;单证型38例,占21.59%;三证型组合52例,占29.55%;四证型组合18例,占10.23%;五证型组合2例,占1.14%。结论:骨肉瘤中医证候要素诊断量表能够为中医证候规范化研究提供可借鉴的思路和方法。

Objective:To explore the distribution and characteristics of traditional Chinese medicine(TCM)syndrome elements in osteosarcoma by using TCM syndrome elements diagnostic scale,and to provide reference for TCM clinical syndrome differentiation.Methods:A multi-center investigation method was adopted to establish a TCM clinical investigation case database for osteosarcoma,and TCM syndrome elements were extracted and analyzed using the TCM syndrome elements diagnostic scale for osteosarcoma.Results:The most common syndromes in 176 patients were blood stasis syndrome,98 cases,accounting for 55.68%;The second was qi deficiency syndrome,76 caces,accounting for 43.18%.Blood deficiency syndrome,65 caces,accounting for 36.93%;Qi-stagnation syndrome was less,28 caces,accounting for 15.91%;Phlegm obstruction syndrome,26 caces,accounting for 14.77%.In 176 patients with osteosarcoma,there were no syndrome type,single syndrome type,two-syndrome combination,three-syndrome combination,four-syndrome combination and five-syndrome combination.There were 56 cases of double syndrome combination,accounting for 31.82%.There were 10 cases of unlicensed type,accounting for 5.68%.There were 38 cases of single syndrome type,accounting for 21.59%.There were 52 cases of three-syndrome type,accounting for 29.55%.There were 18 cases with four-syndrome type,accounting for 10.23%.There were 2 cases of five-syndrome type,accounting for 1.14%.Conclusion:The TCM syndrome elements diagnostic scale of osteosarcoma can provide a reference for the standardization of TCM syndrome research.