固有免疫细胞在宿主抗烟曲霉免疫中的作用

Role of innate immune cells in host immune responses against Aspergillus fumigatus

烟曲霉是一种环境中丝状真菌,也是一种机会致病菌,其感染宿主后能够引起慢性曲霉病和侵袭性曲霉病。曲霉病的发生发展是宿主与病原体相互作用的结果,免疫状态不同的患者感染曲霉后临床症状存在差异。宿主对吸入真菌孢子的固有免疫应答是曲霉病发生的关键决定因素。本综述主要总结了目前对烟曲霉孢子侵入后宿主固有免疫细胞防御真菌感染的作用,包括巨噬细胞、中性粒细胞、自然杀伤细胞、自然杀伤T细胞及肥大细胞,为曲霉感染的致病机制解析、临床防治等相关研究提供一定的参考。

Aspergillus fumigatus(A.fumigatus)is an environmental filamentous fungus and an opportunistic pathogen that can cause chronic and invasive aspergillosis.The development of aspergillosis is the result of the interaction between the host and the pathogen,and the symptoms of A.fumigatus infection varied in patients with different immune status.The host innate immune response to inhaled fungal spores is a key determinant of the development of aspergillosis.This review focused on the role of innate immune cells including macrophages,neutrophils,natural killer cells,natural killer T cells and mast cells in host defense against A.fumigatus,aiming to provide reference for further research on the pathogenesis,clinical prevention and treatment of aspergillosis.