摘要
The catalyticα-C–H fluorination of aryl acetic acids was achieved with good functional group tolerance in the presence of a boron catalyst.A series ofα-fluoro aryl acetic acids were obtained in a single step with high yields(up to 96%).The catalytic reaction was employed for the synthesis of bioactive molecules and the modification of profen drugs.Moreover,the reaction could be performed on a gram scale.Further transformations were carried out.
基金
We appreciate Sichuan Agricultural University for financial support.
