摘要
A new method for the synthesis of 3-ethynyl-1-methylene-1,2-dihydronaphthalenes via copper-pro-moted palladium-catalyzed intermolecular alkynylative[5+1]carboannulation of 1-arylphenyl-prop-2-yn-1-yl acetates involving C–H functionalization is described.Two terminal alkyne molecules serve as an alkynylation reagent and a one-carbon unit to enable alkynylative[5+1]carboannulation with excellent selectivity control,broad substrate scope and good tolerance of functional groups.
基金
We thank the National Natural Science Foundation of China(No.21625203 and 21871126)
the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2021ZD01)for financial support.
