CysC、cTnI水平及心功能指标对AMI患者PCI术后短期预后的预测价值

The Predictive Value of CysC,cTnI Levels and Cardiac Function Indexes on Short-Term Prognosis of Patients with AMI After PCI

目的 探讨胱抑素C(CysC)、心肌肌钙蛋白I(cTnI)水平及心功能指标对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后短期预后的预测价值。方法 选取2020年11月至2021年11月我院收治的120例接受PCI的AMI患者为研究对象,患者出院时检测CysC、cTnI水平及心功能指标,随访3个月后统计不良心血管事件发生情况并根据有无发生其情况分为预后良好组、预后不良组,比较两组基本资料、CysC、cTnI水平及心功能指标,分析以上指标对不良心血管事件危险因素及预测价值并绘制ROC曲线。结果 AMI患者PCI术后3个月不良心血管事件发生率为38.33%(46/120);预后不良组CysC、cTnI水平高于预后良好组,LVEF低于预后良好组(P<0.05);CysC、cTnI升高,LVEF降低是AMI患者PCI术后短期发生不良心血管事件的危险因素(P<0.05);CysC、cTnI水平及LVEF预测AMI患者PCI术后短期不良预后的AUC为0.606、0.743、0.743,具有一定预测价值,联合预测AUC为0.855,预测价值更高。结论 CysC、cTnI水平及LVEF对AMI患者PCI术后短期预后具有预测价值,CysC、cTnI升高,LVEF降低是AMI患者PCI术后发生不良心血管事件的危险因素。

Objective To explore the predictive value of cystatin C(CysC),cardiac troponin-I(cTnI)levels and cardiac function indexes in short-term prognosis of patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 120 AMI patients who underwent PCI in our hospital from November,2020 to November,2021 were selected as the research objects.Levels of CysC,cTnI and cardiac function indexes were detected at the discharge time from the hospital.After 3 months of follow-up,patients with occurrence of adverse cardiovascular events were counted and divided into a good prognosis group and a poor prognosis group according to whether they occurred or not.The basic data,CysC,cTnI levels and cardiac function indexes were compared between the two groups.The risk factors and predictive value of the above indexes for adverse cardiovascular events were analyzed,and the ROC curve was drawn.Results The incidence of adverse cardiovascular events at 3 months after PCI in AMI patients was 38.33%(46/120);Levels of CysC and cTnI in the poor prognosis group were higher than those in the good prognosis group,and LVEF was lower than that in the good prognosis group(P<0.05);Increased CysC and cTnI and decreased LVEF were risk factors for short-term adverse cardiovascular events after PCI in patients with AMI(P<0.05);AUCs of CysC,cTnI levels and LVEF in predicting the short-term poor prognosis of AMI patients after PCI were 0.606,0.743 and 0.743,respectively.The combined prediction AUC was 0.855,suggested a higher predictive value.Conclusion CysC,cTnI levels and LVEF have predictive values for the short-term prognosis of AMI patients after PCI.CysC,cTnI increase and LVEF decrease are risk factors for adverse cardiovascular events after PCI in AMI patients.