摘要
The high incidence and disability rates of stroke pose a heavy burden on society.Inflammation is a significant pathological reaction that occurs after an ischemic stroke.Currently,therapeutic methods,except for intravenous thrombolysis and vascular thrombectomy,have limited time windows.Mesenchymal stem cells(MSCs)can migrate,differentiate,and inhibit inflammatory immune responses.Exosomes(Exos),which are secretory vesicles,have the characteristics of the cells from which they are derived,making them attractive targets for research in recent years.MSC-derived exosomes can attenuate the inflammatory response caused by cerebral stroke by modulating damage-associated molecular patterns.In this review,research on the inflammatory response mechanisms associated with Exos therapy after an ischemic injury is discussed to provide a new approach to clinical treatment.
基金
National Natural Science Foundation of China,No.81974564 and No.82104730
the Zhongyuan Science and Technology Innovation Leading Talent Project,No.224200510027
the National Natural Science Foundation of China,No.82001973
the Youth Project Co-established by Henan Province and a Ministry grant,No.SBGJ2020003017
the Health Science and Technology Innovation Excellent Youth Training Project in Henan Province,No.YXKC2020057.
