粪肠球菌在酒精性肝病中的研究进展

Research advances in the role of Enterococcus faecalis in alcoholic liver disease

酒精性肝病(ALD)是世界范围内最常见的慢性肝病之一,包括脂肪变性、脂肪性肝炎、纤维化和肝硬化不同阶段。粪肠球菌是医院常见获得性感染菌群,对于酒精性肝炎患者预后具有重要影响。本篇综述重点介绍了ALD的发病因素和粪肠球菌的致病机理,总结了粪肠球菌在ALD中的研究进展,简述了临床上对于粪肠球菌感染的检测和治疗方法。由于临床上感染溶细胞性粪肠球菌的ALD患者死亡率极高,因此深入认识粪肠球菌成为当下重要问题。

Alcoholic liver disease(ALD)is one of the most common chronic liver diseases worldwide and includes the different stages of steatosis,steatohepatitis,fibrosis,and liver cirrhosis.Enterococcus faecalis is a common bacterium for nosocomial infection and has a significant impact on the prognosis of patients with alcoholic hepatitis.This review mainly introduces the pathogenesis of ALD and the pathogenic mechanism of E.faecalis,summarizes the research advances in E.faecalis in ALD,and briefly describes the detection and treatment methods for E.faecalis infection in clinical practice.Since there is an extremely high mortality rate in ALD patients with lytic E.faecalis infection,an in-depth understanding of E.faecalis has become an important issue nowadays.