脂多糖在肝癌发生发展中的作用

Role of lipopolysaccharide in the development and progression of liver cancer

肝癌是世界范围重大的公共卫生疾病。近来随着高通量测序及基因编辑技术的进步,肠道微生物群通过“肝-肠轴”途径在肝癌发生、进展及转移过程中的生物学机制被进一步揭示,特别是发现革兰阴性细菌外膜脂多糖可动员下游一系列致癌相关免疫级联反应。本文从肠道环境改变与肝癌发生的关系、脂多糖免疫调控、临床前治疗研究等方面,对肠道微生物脂多糖在肝癌发生发展中的可能作用机制进行了综述。

Liver cancer is an important public health issue worldwide.With the improvements in high-throughput sequencing and gene editing techniques in recent years,studies have further revealed the biological mechanism of intestinal microflora in the development,progression,and metastasis of liver cancer via the gut-liver axis,and in particular,it has been found that lipopolysaccharide,a component of the outer membrane of gram-negative bacteria,can cause downstream immune cascade reactions.This article reviews the possible mechanism of action of intestinal microflora lipopolysaccharide in the development and progression of liver cancer from the aspects of the association between intestinal environmental changes and liver cancer,immunoregulation by lipopolysaccharide,and preclinical treatment.