外用域发液体敷料联合微针治疗雄激素性脱发的疗效观察

Comparative Study on the Efficacy of Yufa Solution Combined with Microneedling in the Treatment of Androgenetic Alopecia

目的:观察外用域发液体敷料联合微针治疗雄激素性脱发的临床疗效。方法:将入组的27例AGA患者脱发区随机分为两组,一侧给予外用域发液体敷料单药治疗(对照组),每天两次,另一侧头皮给予外用域发液体敷料外用治疗结合微针导入治疗(治疗组),微针治疗每周1次,12周为一个疗程。应用毛发镜联合毛发图像分析比较毛发密度及毛干直径、终毛毳毛比例和单根毛发毛囊比例差异。结果:疗程结束后,对照组毛发平均密度由(132.4±25.9)fu/cm^(2)增加至(138.8±28.7)fu/cm^(2);治疗组毛发平均密度由(127.3±27.6)fu/cm^(2)增加至(152.2±30.0)fu/cm^(2),治疗组毛发平均直径由(0.069±0.013)mm增加至(0.074±0.015)mm,差异均具有统计学意义(P<0.05);毛发平均密度治疗组高于对照组(P<0.05);治疗组终毛毳毛比值从(7.9±6.0)增加至(9.1±7.7),单根毛发毛囊比例由57.1%±10.0%降低至48.8%±10.0%,差异有统计学意义(P<0.05);对照组治疗前后、以及两组治疗后终毛毳毛比值和单根毛发毛囊比例比较差异均无统计学意义(P>0.05)。结论:外用域发液体敷料联合微针治疗雄激素性脱发安全、有效。

Objective To observe the clinical efficacy of YuFa solution combined with microneedling in the treatment of androgenetic alopecia.Methods The 27 patients with AGA enrolled in the group were randomly divided into two groups,with one side given topical liquid domain hair dressing monotherapy twice daily(control group)and the other side of the scalp treated with topical liquid domain hair dressing twice daily combined with microneedling introduction(treatment group),once a week for 12 weeks as a course of treatment.dermoscopic analysis and trichoscan analysis were applied to compare the difierences in hair density and diameter,the ratio of terminal hair to vellus hair and the ratio of single hair follicles.Results The mean hair density increased from(132.4±25.9)fu/cm^(2) to(138.8±28.7)fu/cm^(2) on the side treated with YuFa alone(P<0.05).The mean hair density increased from(127.3±27.6)fu/cm^(2) to(152.2±30.0)fu/cm^(2) on the combination treatment side(P<0.001),and the mean hair diameter increased from(0.069±0.013)mm to(0.074±0.015)mm on the combination side(P<0.05).After treatment,the mean hair density was higher on the combination treatment side than YuFa side(P<0.05).Before and after treatment,the terminal/vellus hair increased from 7.9±6.0 to 9.1±7.7(P<0.05)and the proportion of single hair follicles decreased from57.1%±10.0%to 48.8%±10.0%(P<0.05)on the treatment group.No statistically significant difierences were found before and after treatment on the topical drug side alone,as well as in the comparison of the terminal/vellus hair and the proportion of single hair follicles on both sides after treatment(P>0.05).Conclusion YuFa solution combined with microneedling for androgenetic alopecia is safe and efiective.