阿司匹林联合替格瑞洛治疗急性心肌梗死合并心力衰竭疗效观察

Curative Effect of Aspirin Combined with Ticagrelor in the Treatment of Acute Myocardial Infarction Complicated with Heart Failure

目的:研究阿司匹林联合替格瑞洛治疗急性心肌梗死合并心力衰竭患者疗效。方法:选取2021年8月至2022年4月河南电力医院诊治的84例急性心肌梗死并发心力衰竭患者作为研究对象,采用随机数表法分为对照组和观察组,各42例。对照组采用阿司匹林肠溶片治疗,观察组采用阿司匹林肠溶片联合替格瑞洛治疗。比较两组患者疗效、心脏超声指标、凝血功能、心肌酶谱及心力衰竭标志物、不良反应发生情况的差异。结果:观察组患者治疗总有效率显著高于对照组患者,差异具有统计学意义(P<0.05)。治疗后,两组患者左室舒张末期内径(LVEDD)、Tei指数、肌酸激酶同工酶MB(CK-MB)、高敏心肌肌钙蛋白I(hs-cTnI)和N末端B型利钠肽原(NT-proBNP)较治疗前显著降低,且观察组均低于对照组;左室射血分数(LVEF)显著升高,且观察组高于对照组,差异均具有统计学意义(P<0.05);两组患者组内及组间凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)及血小板(Plt)比较,差异均无统计学意义(P>0.05);两组患者治疗期间不良反应发生情况比较,差异无统计学意义(P>0.05)。结论:阿司匹林联合替格瑞洛可显著改善急性心肌梗死合并心力衰竭患者的心功能、凝血功能、心肌酶谱及心力衰竭标志物指标,其疗效更好。

Objective To study the curative effect of aspirin combined with ticagrelor in the treatment of patients with acute myocardial infarction complicated with heart failure.Methods A total of 84 patients with acute myocardial infarction complicated with heart failure who were diagnosed and treated in Henan Electric Power Hospital from August 2021 to April 2022 were selected as the research objects,and they were divided into a control group and an observation group by random number table method,with 42 cases in each group.The control group was treated with aspirin enteric-coated tablets,and the observation group was treated with aspirin enteric-coated tablets combined with ticagrelor.The differences in curative effect,echocardiographic indexes,coagulation function,myocardial enzyme spectrum,heart failure markers,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular end-diastolic diameter(LVEDD),Tei index,creatine kinase isoenzyme MB(CK-MB),high-sensitivity cardiac troponin I(hs-cTnI)and N terminal pro-B type natriuretic peptide(NT-proBNP)of the two groups were significantly lower than those before treatment,and the indexes of the observation group were lower than those of the control group;the left ventricular ejection fraction(LVEF)was significantly increased,and the observation group was higher than that of the control group,and the differences were all statistically significant(P<0.05);there was no significant difference in prothrombin time(PT),activated partial thromboplastin time(APTT)and platelet(Plt)between the two groups(P>0.05);There was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion Aspirin combined with ticagrelor can significantly improve cardiac function,coagulation function,myocardial enzyme spectrum and heart failure markers in patients with acute myocardial infarction complicated with heart failure,and its efficacy is better.