PET/CT在分化型甲状腺癌中的应用价值

The Application Value of PET/CT in Differentiated Thyroid Cancer

在过去数十年间,临床医师对分化型甲状腺癌(DTC)的认识不断提高,这与影像检查的不断改进息息相关,其中正电子发射断层扫描/计算机断层扫描(PET/CT)是最令人关注的诊断工具。氟代脱氧葡萄糖(^(18)F-FDG)是临床肿瘤学中应用最广泛的PET放射性药物,同时也是应用于甲状腺肿瘤的最常见的PET显像剂。除了^(18)F-FDG,其他示踪剂也可用于甲状腺肿瘤的PET成像,如氟^(18)-四氟硼酸盐(^(18)F-TFB)、镓^(68)-前列腺特异性膜抗原(^(68)Ga-PSMA)和放射性核素标记的成纤维细胞激活蛋白抑制剂(FAPI)。本研究将从临床应用方面总结PET/CT在DTC患者诊疗中的作用。

In the past decades,the clinical physicians’awareness of differentiated thyroid cancer has been constantly improved,which is closely related to the continuous improvement of image examination,among which positron emission tomography/computed tomography(PET/CT)has attracted more and more attention these years.^(18)F-fluorodeoxyglucose(^(18)F-FDG)is the PET imaging tracer which is the most commonly used in clinical oncology,and it is also the most common PET imaging agent used in thyroid tumors.Beyon ^(18)F-FDG,other tracers can also be used for PET imaging of thyroid tumors,such as ^(18)F-tetrafluoroborate(^(18)F-TFB),^(68)Gaprostate-specific membrane antigen(^(68)Ga-PSMA)and radionuclide labeled fibroblast activation protein inhibitor(FAPI).This review will summarize the role of PET/CT in the diagnosis and treatment of DTC patients from the perspective of clinical application.