食管鳞癌患者高血压患病情况及临床分布特征

Incidence and clinical distribution characteristics of hypertension in patients with esophageal squamous cell carcinoma

目的 分析食管鳞癌患者高血压患病情况,探讨其与食管鳞癌临床病理特征的关系。方法 49 463例食管鳞癌患者,依据血压分为正常血压组(收缩压<120 mm Hg且舒张压<80 mm Hg)、正常高值血压组(收缩压120~139 mm Hg和/或舒张压80~89 mm Hg)、1级高血压组(收缩压140~159 mm Hg和/或舒张压90~99 mm Hg)、2级高血压组(收缩压160~179 mm Hg和/或舒张压100~109 mm Hg)、3级高血压组(收缩压≥180 mm Hg和/或舒张压≥110 mm Hg)和单纯收缩期高血压组(收缩压≥140 mm Hg且舒张压<90 mm Hg)。比较不同性别、年龄、职业、食管癌发病地区、居住地、肿瘤家族史、肿瘤部位、TNM分期以及有无淋巴结转移者的血压分级情况。结果 (1)49 463例中,正常血压11 360例(22.97%),正常高值血压21 155例(42.77%),1级高血压6 693例(13.53%),2级高血压2 857例(5.78%),3级高血压1 015例(2.05%),单纯收缩期高血压6 383例(12.90%)。(2)不同性别、职业及有无肿瘤家族史者血压分级比较差异均有统计学意义(P<0.05),不同肿瘤部位、TNM分期、发病地区、居住地及有无淋巴结转移者血压分级比较差异均无统计学意义(P>0.05)。(3)正常血压、正常高值血压、1级高血压、2级高血压、3级高血压、单纯收缩期高血压组年龄50~<60岁、60~<70岁者比率均高于年龄<40岁、40~<50岁、70~<80岁、≥80岁者(P<0.05)。结论 食管鳞癌患者正常高值血压及高血压发病率较高,血压分布与性别、职业及肿瘤家族史有关,高血压发病高峰为50~<70岁。

Objective To analyze the incidence of hypertension in patients with esophageal squamous cell carcinoma(ESCC),and to investigate its relationship with the clinicopathologic characteristics of ESCC.Methods Totally 49463 ESCC patients were divided into normal blood pressure group[systolic blood pressure(SBP):<120 mm Hg and diastolic blood pressure(DBP):<80 mm Hg],high-normal blood pressure group(SBP:120-139 mm Hg and/or DBP:80-89 mm Hg),grade 1 hypertension group(SBP:140-159 mm Hg and/or DBP:90-99 mm Hg),grade 2 hypertension group(SBP:160-179 mm Hg and/or DBP:100-109 mm Hg),grade 3 hypertension group(SBP:≥180 mm Hg and/or DBP:≥110 mm Hg)and isolated systolic hypertension group(SBP:≥140 mm Hg and DBP:<90 mm Hg).The blood pressure grade was compared in patients with different gender,age,occupation,area,residence,tumor family history,tumor location,TNM stage and lymph node metastasis.Results(1)Among 49463 patients,11360(22.97%)had normal blood pressure,21155(42.77%)had high-normal blood pressure,6693(13.53%)had grade 1 hypertension,2857(5.78%)had grade 2 hypertension,1015(2.05%)had grade 3 hypertension,and 6383(12.90%)had isolated systolic hypertension.(2)The distribution of blood pressure showed significant differences in patients with different gender,occupations and tumor family history(P<0.05),and showed no significant differences in patients with different tumor location,TNM stage,area,residence and lymph node metastasis(P>0.05).(3)The percentages of patients aged 50 to <60 years and 60 to <70 years were higher than those of patients aged <40 years,40 to <50 years,70 to <80 years,and≥80 years in all six groups(P<0.05).Conclusions ESCC patients have high incidences of high-normal blood pressure and hypertension.The distribution of hypertension is correlated with the gender,occupation and tumor family history.The peak age of incidence of hypertension is 50 to 70 years old.