摘要
高尿酸血症是心房颤动发生的独立危险因素,其可能通过氧化应激、炎症、肾素-血管紧张素-醛固酮系统、尿酸沉积等途径诱发心房颤动,引起心房电重构和结构重构,促进心房颤动的发生和发展。目前高尿酸血症在心房颤动发病中的作用机制尚未阐明。本文就高尿酸血症与心房颤动的关系、高尿酸血症引起心房颤动可能机制的研究进展作一综述。
Hyperuricemia is an independent risk factor of atrial fibrillation,and it may cause electrical and structural remodeling of the atria and promote the occurrence and development of atrial fibrillation via oxidative stress,inflammatory response,renin-angiotensin-aldosterone system,and uric acid deposition,etc.The mechanism of hyperuricemia in atrial fibrillation has not been elucidated.This paper reviews the relationship between hyperuricemia and atrial fibrillation and its potential pathogenesis of atrial fibrillation induced by hyperuricemia.
作者
余鹏程
雷桅
何原
黄石安
YU Peng-cheng;LEI Wei;HE Yuan;HUANG Shi-an(Cardiovascular Medicine Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong 52400l,China;Department of Precision Laboratory,Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong 524001,China;Laboratory of Cardiovascular Diseases,Guangdong Medical University,Zhanjiang,Guangdong 524023,China)
出处
《中华实用诊断与治疗杂志》
2023年第5期537-540,共4页
Journal of Chinese Practical Diagnosis and Therapy
基金
广东医科大学学科建设类二级项目(4SG21233G)
湛江市科技计划项目(2020A06004)。
关键词
高尿酸血症
心房颤动
氧化应激
炎症
hyperuricemia
atrial fibrilation
oxidative stress
inflammation
