2型糖尿病患者运动响应异质性的研究进展

A Progress Review in Exercise Response Heterogeneity in Patients with Type 2 Diabetes

2型糖尿病(T2D)是当前威胁我国居民健康的主要慢性疾病之一。许多研究表明运动能够有效改善T2D患者血糖控制。但是,个体对于运动的响应存在差异,即运动响应异质性。查阅有关T2D运动干预的研究,发现T2D患者个体的血糖稳态对运动干预的响应并不一致,且存在特定运动下血糖稳态未改善(无响应)的个体。遗传、代谢、炎症和肠道菌群可能是导致运动响应异质性的原因。已有少量研究开始探索基于个体特征评估T2D患者对于运动干预的响应,使运动能够精准服务于那些最有可能受益的人,并探索新的策略来帮助无响应者获得健康益处。

Type 2 diabetes(T2D)is one of the major chronic diseases threatening the public health globally.Previous studies have shown that exercise can effectively improve glycemic control in patients with T2D.However,individual patient has different response to exercise interventions.This is known as exercise response heterogeneity.Genetics,metabolism,inflammation and gut microbiota may contribute to the heterogeneity of exercise response.Recently,exercise response heterogeneity has become a new focal point in T2D patients'research.The outcome of these research could pave the way for the development of precision treatment strategies for chronic metabolicdiseases.