系统性红斑狼疮相关重叠综合征的研究进展及应对策略

Research progress in overlap syndrome associated with systemic lupus erythematosus and its management strategies

重叠综合征是一种符合至少两种结缔组织疾病标准的综合征。系统性红斑狼疮与系统性硬化症、皮肌炎/多发性肌炎、干燥综合征、类风湿性关节炎等疾病发生重叠时,缺乏特异性的血清学指标及临床表现,可能出现漏诊、误诊,严重时可危及生命。早期识别和治疗重叠综合征有助于减轻对患者生活质量的影响,改善患者预后。本文对SLE相关重叠综合征研究进展及其应对策略进行综述,发现目前对SLE相关重叠综合征研究较少,但其临床表现及免疫学特征与其所重叠的疾病强烈相关,及时对病人进行特定的检查可以发现疾病的发生,为临床诊断和治疗提供参考。

Overlapping syndrome is a syndrome that meets the criteria for at least two connective tissue diseases.When systemic lupus erythematosus(SLE)overlaps with systemic sclerosis(SSc),dermatomyositis/polymyositis,Sjogren's syndrome(SS),rheumatoid arthritis(RA),and other diseases,the lack of specific serological indicators and clinical manifestations can result in missed diagnosis and/or misdiagnosis,leading to life-threatening in severe cases.Early diagnosis and treatment of overlap syndrome can help alleviate the impact on patients'quality of life and improve the prognosis.This article reviews the research progress in this disorder and its management strategies.Although there is currently limited research on SLE related overlap syndrome,its clinical manifestations and immunological characteristics are strongly related to the overlapping diseases.Specific tests and examinations in time can facilitate the diagnosis and treatment of overlap syndrome.