安宫牛黄丸对高血压性脑出血术后患者神经功能、炎症因子及生活质量的影响

Effects of Angong Niuhuang Pills on Neurological Function,Inflammatory Factors and Quality of Life in Patients After Operation for Hypertensive Intracerebral Hemorrhage

目的:观察安宫牛黄丸辅助治疗高血压性脑出血术后患者对神经功能、炎症因子及生活质量的影响。方法:将80例高血压性脑出血手术患者按照随机数字表法分为对照组和观察组各40例。对照组术后给予常规治疗,观察组在对照组的基础上给予安宫牛黄丸治疗。比较2组炎症因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平、神经功能因子[神经元特异性烯醇化酶(NSE)、神经肽(NP)Y、脑源性神经营养因子(BDNF)]水平、美国国立卫生研究院脑卒中量表(NIHSS)及生活质量评分表(ADL)评分,以及临床疗效、不良反应发生率。结果:观察组总有效率为95.00%,对照组为77.50%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组血清IL-6、IL-8、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,2组IL-6、IL-8、TNF-α水平均较治疗前降低(P<0.05),且观察组上述3项指标均低于对照组(P<0.05)。治疗前,2组血清NSE、NPY、BDNF水平比较,差异无统计学意义(P>0.05)。治疗后,2组NSE、NPY水平均较治疗前降低(P<0.05),BDNF水平较治疗前升高(P<0.05);且观察组上述3项改善较对照组更显著(P<0.05)。治疗前,2组NIHSS、ADL评分比较,差异无统计学意义(P>0.05)。治疗后,2组NIHSS评分均较治疗前降低(P<0.05),ADL评分均较治疗前升高(P<0.05);且观察组NIHSS、ADL评分改善较对照组更显著(P<0.05)。观察组不良反应发生率为7.50%,对照组为25.00%,2组比较,差异有统计学意义(P<0.05)。结论:对高血压性脑出血术后患者采用安宫牛黄丸辅助治疗,能够改善患者的神经功能,降低炎症因子水平,提高生活质量,且不良反应较少。

Objective:To observe the effect of Angong Niuhuang Pills on neurological function,inflammatory factors and quality of life in patients after operation for hypertensive intracerebral hemorrhage(HICH).Methods:A total of 80 cases of patients with HICH were divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was given routine treatment after operation,and the observation group was additionally treated with Angong Niuhuang Pills based on the treatment of the control group.The levels of inflammatory factors including interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α),neurofunctional factors including neuron-specific enolase(NSE),neuropeptide(NP)Y and brain-derived neurotrophic factor(BDNF-α),National Institutes of Health Stroke Scale(NIHSS)scores,Activities of Daily Living(ADL)scores,clinical effects,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment was 95.00%in the observation group and77.50%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of IL-6,IL-8 and TNF-αin serum between the two groups(P>0.05).After treatment,the levels of IL-6,IL-8 and TNF-αin the two groups were decreased when compared with those before treatment(P<0.05),and the above three levels in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of NSE,NPY and BDNF in serum between the two groups(P<0.05).After treatment,the levels of NSE and NPY in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of BDNF in the two groups were increased when compared with those before treatment(P<0.05);the improvement of the above three levels in the observation group was more significant than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the scores of NIHSS and ADL between the two groups(P<0.05).After treatment,NIHSS scores in the two groups were decreased when compared with those before treatment(P<0.05),and ADL scores in the two groups were increased when compared with those before treatment(P<0.05);the improvement of the scores of NIHSS and ADL in the observation group was more significant than that in the control group(P<0.05).The incidence of adverse reactions was 7.50%in the observation group and 25.00%in the control group,the difference being significant(P<0.05).Conclusion:The adjuvant therapy of Angong Niuhuang Pills for patients after HICH operation can improve their neurological function,reduce the levels of inflammatory factors and enhance the quality of life,with fewer adverse reactions.