CA125、CA19-9、SCC联合检测在早期宫颈癌诊断中的应用

Application of Combined Detection of CA125,CA19-9 and SCC in the Diagnosis of Early Cervical Cancer

目的研究糖链抗原125(carbohydrate antigen 125,CA125)、糖链抗原19-9(carbohydrate antigen 19-9,CA19-9)、鳞状细胞癌抗原(squamous cell carcinomaantigen,SCC)联合检测在早期宫颈癌诊断中的应用。方法选择2020年1月至2021年6月我院收治的75例宫颈癌筛查者为研究对象,依据病理检查结果分为对照组(宫颈良性疾病,35例)及研究组(宫颈癌,40例)。检测两组患者血清CA125、CA19-9、SCC水平,分析不同分化程度的宫颈癌患者血清CA125、CA19-9、SCC表达水平,不同病理类型的宫颈癌患者血清CA125、CA19-9、SCC表达水平,分析血清CA125、CA19-9、SCC表达水平单项及联合检测对早期宫颈癌的诊断价值。结果研究组血清肿瘤标志物CA125、CA19-9、SCC表达水平均高于对照组,组间比较差异均具有统计学意义(P<0.05);宫颈癌患者肿瘤分化程度越低,肿瘤标志物CA125、CA19-9、SCC表达水平越高,高分化宫颈癌患者血清肿瘤标志物CA125、CA19-9、SCC表达水平低于中低分化患者,组间比较差异均具有统计学意义(P<0.05);宫颈鳞状上皮细胞癌患者血清SCC水平高于宫颈腺癌患者,CA125、CA19-9均明显低于宫颈腺癌患者,组间比较差异均具有统计学意义(P<0.05);ROC曲线显示,与CA125、CA19-9、SCC单项预测相比,三项联合检测对早期宫颈癌的诊断价值较高(P<0.05)。结论CA125、CA19-9、SCC在早期宫颈癌患者血清中出现异常表达,检测CA125、CA19-9、SCC表达水平对早期宫颈癌具有较高的诊断价值,可尽早制定相关措施干预,提高临床疗效。

Objective To study the application of combined detection of carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9)and squamous cell carcinomaantigen(SCC)in the diagnosis of early cervical cancer.Methods From January 2020 to June 2021,75 patients with high risk of cervical cancer were selected as the research objects,and according to the pathological examination results,they were divided into the control group(35 patients with benign cervical diseases)and the research group(40 patients with cervical cancer).The levels of serum CA125,CA19-9 and SCC in two groups of patients were detected.The expression levels of serum CA125,CA19-9 and SCC in cervical cancer patients with different differentiation degrees and those in cervical cancer patients with different pathological types were analyzed.The diagnostic value of single and combined detection of serum CA125,CA19-9 and SCC in early cervical cancer was analyzed.Results The expression levels of serum tumor markers CA125,CA19-9 and SCC in the study group were higher than those in the control group,and the differences between the two groups were statistically significant(P<0.05).The lower the degree of cervical cancer differentiation,the higher the expression levels of tumor markers CA125,CA19-9 and SCC.The expression levels of serum tumor markers CA125,CA19-9 and SCC in highly differentiated cervical cancer patients were lower than those in moderately and poorly differentiated cervical cancer patients,and the differences between groups were statistically significant(P<0.05).Serum SCC level in patients with squamous cell carcinoma of cervix was higher than that in patients with adenocarcinoma of cervix,and CA125 and CA19-9 were significantly lower than those in patients with adenocarcinoma of cervix,and the differences between groups were statistically significant(P<0.05).ROC curve showed that the combined detection of CA125,CA19-9 and SCC had higher diagnostic value in early cervical cancer than single prediction(P<0.05).Conclusion Abnormal expression of CA125,CA19-9 and SCC appears in the serum of patients with early cervical cancer.Detection of the expression level of CA125,CA19-9 and SCC is of high diagnostic value for early cervical cancer,and relevant measures can be formulated as soon as possible to improve the treatment efficiency.