儿童中药制剂掩味及口感评价方法研究进展

Research Progress on Taste Masking and Taste Evaluation Methods of Tradtional Chinese Medicine for Pediatric

研制适合儿童的药物是治疗儿童疾病的先决条件,尤其是药物的味道。中药的掩味研究,具有很强的挑战性,特别是治疗儿童患者的中药制剂。儿童中药口服固体制剂具有携带方便、便于储存等优点,但往往具有苦味等不良口感,大大降低了儿童对于中药的接受程度,导致服药剂量不准确。掩味技术的应用是改善药物口感最直接的方式,体内及体外口感评价技术对于药物制剂的口感改善起决定性作用。就近年来儿童中药口服固体制剂的掩味技术及口感评价方法进行综述,同时对矫味剂的安全性进行总结归纳,旨在为儿童中药口服固体制剂的掩味研究提供参考。

Medicines suitable for children are a prerequisite for treating children diseases,especially the taste of drugs.The study of traditional Chinese medicine is very challenging,es-pecially for the treatment of pediatric patients.Oral solid dosage of tradtional Chinese medicine which are convenient for carry and storage,but often has bad taste such as bitter taste,which greatly reduces children acceptance of tradtional Chinese medicine,resulting in inaccurate dosage.The application of taste masking technology is the most direct way to impr-ove the taste of drugs.In vivo and in vitro taste evaluation technology plays a decisive role in improving the taste of drug preparations.This paper reviews the taste masking techniques and taste evaluation methods of oral solid preparations of traditional Chinese medicine for chil-dren in recent years,and summarizes the safety of flavor correction agents,so as to provide reference for the research on taste masking of oral solid preparations of traditional Chinese medicine for children.