蟾酥及其制剂抗肿瘤作用研究进展

Research Progress on Antitumor Effect of Bufonis Venenum and its Preparations

蟾酥作为一种天然药物,具有显著的抗炎、镇痛、抗肿瘤等药理作用。蟾酥是数十种中药制剂的主要原料,在肺癌、肝癌、前列腺癌等各种晚期肿瘤的治疗中具有重要作用。研究发现其抗肿瘤作用可能与抑制肿瘤细胞的增殖、转移、侵袭,诱导肿瘤细胞凋亡和自噬,肿瘤细胞相关性炎症等相关。在临床上,蟾酥及其各种制剂应用广泛,具有极大的研究意义。

As a natural medicine,Bufonis Venenum has significant anti-inflammatory,analgesic,anti-tumor and other pharmacological effects.Toad cake is the main raw material of dozens of traditional Chinese medicine preparations and plays an important role in the treatment of various advanced tumors such as lung cancer,liver cancer and prostate canc-er.Studies have found that its anti-tumor effect may be related to inhibiting the proliferation,metastasis and invasion of tumor cells,inducing tumor cell apoptosis and autophagy,and tumor cell related inflammation.In clinic,Bufonis Vene-num and its various preparations are widely used and have great research significance.