黄芪豆豉对气虚血瘀型大鼠血液流变学的影响

The Effects of Astragali radix-Sojae Semen Praeparatum on Hemorheology in Rats with Qi Deficiency and Blood Stasis

研究黄芪豆豉对气虚血瘀型大鼠血液流变学和其相关因子的影响,探讨其益气活血作用及其机制。采用饥饿加疲劳的方法建立气虚血瘀大鼠模型,考察各组大鼠血流变学指标和因子,分析其益气活血作用。在血流变学指标方面:与模型组相比,空白组的全血高、中、低切,黄芪豆豉高、中、低剂量组的低切、高切,差异极显著;空白组,黄芪豆豉低、中组的全血相对指数低、高切及高剂量组的低切差异极显著;而血浆黏度和红细胞聚集指数无显著性差异。在相关因子方面:模型组大鼠血栓素B_(2) (TXB_(2))和6-酮前列腺素-PGF1α (6-keto-PGF1α)含量比值为0.009 9;黄芪豆豉高、中、低剂量组TXB_(2)与6-keto-PGF1α比值分别为0.003 5,0.002 9和0.004 6。黄芪豆豉通过降低气虚血瘀模型大鼠全血黏度、血浆黏度及血液流变学相关因子含量比值,来改善气虚血瘀状态,从而减轻“血瘀证”,具有活血作用。

It is to study the effects of Astragali radix-Sojae Semen Praeparatum on hemorheology indexes and related factors in rats with Qi deficiency and blood stasis syndrome,and to explore its effect of supplementing qi and promoting blood circulation,as well as the mechanism.Establish the rat model of qi deficiency and blood stasis by hunger and fatigue.In the aspect of blood rheology indicators:compared with the model group,the whole blood viscosity's high,medium,low cut for the blank group,and the whole blood viscosity's low,high cut for the high,medium,low dose of Astragali radix-Sojae Semen Praeparatum show significant differences.The difference in whole blood relative index among the blank group,low and medium groups of Astragali radix-Sojae Semen Praeparatum,high cut,and high-dose groups is extremely significant.There is no significant difference in plasma viscosity and red blood cell aggregation index.In terms of related factors:the content ratio of thromboxane B_2(TXB_2) and 6-ketoprostaglandin PGF1 in model group rats α(6-keto-PGF1α) is 0.009 9.For Astragali radix-Sojae Semen Praeparatum groups with high,medium,and low dose,these ratios are 0.003 5,0.002 9,and 0.004 6,respectively.Astragali radix-Sojae Semen Praeparatum can improve the state of Qi deficiency and blood stasis by reducing the whole blood viscosity,plasma viscosity,and the content ratio of hemorheology related factors in rats with Qi deficiency and blood stasis model,thus reducing the “blood stasis syndrome” and activating blood circulation.