摘要
为了评价布舍瑞林注射液对靶动物猪的安全性,将16头断奶母猪随机分为4组(每组4头),即布舍瑞林1倍、3倍、5倍推荐剂量组以及空白对照组。试验组连续3 d单次颈部肌内给药,对照组不给药。于给药前和最后1次给药结束后1 h内收集血液,测定血常规和血液生化指标;试验结束时对空白对照组和5倍剂量组猪的脏器进行病理学观察;记录试验期间猪的体温变化。结果显示,与空白对照组相比,各给药组猪的体温无显著变化(P>0.05);各给药组的平均红细胞血红蛋白浓度(MCHC)较处理前显著升高(P<0.05),无机磷(P)较处理前显著降低(P<0.05);5倍剂量组钙离子(Ca^(2+))较处理前显著降低(P<0.05),处理后P比同期对照组也显著降低(P<0.05);与对照组相比,各内脏器官未见明显的病理变化。综上所述,3倍及以下剂量布舍瑞林注射液对靶动物猪是安全的。
To evaluate the safety of Buserelin injection on sows,16 weaned sows were randomly divided into 4 groups(4 sows/group):recommended dose group,triple dose group,5-fold dose group and control group.Treated groups received single intramuscular administration under neck consecutively for 3 days,with control sows not received administration.Blood was collected before the first administration and after last administration within 1 h for the detection of blood routine and blood biochemical indexes.At the end of the experiment,internal organs in control and five-fold dose groups were collected for histopathological examinations,the body temperatures of all animals during experiment were recorded.The results showed that:compared with the control group,the temperature of sows in treated groups had no significant different(P>0.05);In all treated groups,the mean corpuscular hemoglobin concentration(MCHC)significantly increased(P<0.05)and inorganic phosphorus(P)significantly decreased after treatment(P<0.05);In 5-fold dose group,the calcium(Ca^(2+))decreased significantly after treatment(P<0.05),P decreased significantly compared with control group(P<0.05);Compared with control group,no obvious histopathological changes were observed in internal organs.In conclusion,the triple dose of Buserelin injection or lower dose is safe on sows.
作者
周乐乐
黄显会
张守全
杨雪
卫恒习
孟立
王建
赵健
李莉
ZHOU Le-le;HUANG Xian-hui;ZHANG Shou-quan;YANG Xue;WEI Heng-xi;MENG Li;WANG Jian;ZHAO Jian;LI Li(College of Animal Science,South China Agricultural University,Guangzhou,Guangdong,510642,China;College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong,510642,China;Tian Jin Zhong Sheng Challenging Animal Health Biotechnical Corporation,Tianjin,300170,China)
出处
《动物医学进展》
北大核心
2023年第8期47-52,共6页
Progress In Veterinary Medicine
基金
“广东省现代农业产业技术体系生猪创新团队”项目(2020KJ126)。